Fast, flexible, and robust denoising of nucleotide sequences Long Description (required) DUDE-Seq considers the correction of errors from nucleotide sequences produced by next-generation sequencing. Our methodology, named DUDE-Seq, is derived from a general setting of reconstructing finite-valued source data corrupted by a discrete memoryless channel and provides an effective means for correcting substitution and homopolymer indel errors. Our experimental studies with real and simulated data sets suggest that the proposed DUDE-Seq outperforms existing alternatives in terms of error-correction capabilities, time efficiency, as boosting the reliability of downstream analyses. Further, DUDE-Seq is universally applicable across different sequencing platforms and analysis pipelines by a simple update of the noise model. http://data.snu.ac.kr/pub/dude-seq/ email@example.com Step 1: Use the attribute tree to add new attributes or remove pre-selected attributes to describe the simulator. Every sub-attribute is selected Not all sub-attributes are selected Fill Clear Expand Collapse Reset Summary of Proposed Changes Step 2: Review list of proposed attribute addition(s) and subtraction(s). Can't Find the Attribute You Are Looking For?
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DUDE-Seq: Fast, flexible, and robust denoising for targeted amplicon sequencing. PLoS One,
https://www.ncbi.nlm.nih.gov/pubmed/?term=28749987, Primary Citation