Early Stopping Options

Since Hudson's Method is computationally intensive, Early Stopping Options have been added so that not all permutations need to be analyzed. The options are:

• Fixed - all permuted data sets are analyzed, with the default being 4499.

• B-Value - the maximum number of permuted data sets to be analyzed is determined by the significance level specified, using a less conservative approach. See Fay et al. for details (Fay, MP, Kim, H-J, and Hachey, M. (2007) "On using Truncated Sequential Probability Ratio Test Boundaries for Monte Carlo Implementation of Hypothesis Tests" (Journal of Computational and Graphical Statistics 16, 946-967).

• Curtailed - the maximum number of permuted data sets to be analyzed is determined by the significance level specified, using a more conservative approach.

This option is not currently available for the Grid Search Method but may be added in a future version of the software.