GSR: Simulator - FastSLINK

Basic Package Attributes
AttributeValue
Title FastSLINK
Short Description Simulation of Marker and Phenotype Data in Pedigrees
Long Description FastSLINK permits simulation of marker and phenotype data in large pedigrees. Both power and significance can be evaluated. FastSLINK also supports locus heterogeneity.
Version 3.0
Project Started 1990
Last Release 9 years, 11 months ago
Homepagehttps://watson.hgen.pitt.edu/register/soft_doc.html
Citations Ott J, Computer-simulation methods in human linkage analysis., Proc Natl Acad Sci U S A, 06-01-1989 [ Abstract, cited in PMC ]
GSR Certification

Accessibility
Documentation
Application
Support

Last evaluated04-05-2018 (926 days ago)
Detailed Attributes
Attribute CategoryAttribute
Target
Type of Simulated DataGenotype at Genetic Markers, Haploid DNA Sequence, Sex Chromosomes,
VariationsBiallelic Marker, Multiallelic Marker, Single Nucleotide Variation, Microsatellite, Missing Genotypes,
Simulation MethodOther (Elston-stewart method, adapted by dr. ott.),
Input
Data TypeAllele Frequencies, Other (Observed pedigree structure, phenotypes and indication of which individuals are available),
File formatOther (Linkage),
Output
Data TypeGenotype or Sequence (Option to include observed genotype), Phenotypic Trait,
Sequencing ReadsOther (Power and significance),
File FormatLinkage, Program Specific (Text format for summary statistics),
Sample TypeSibpairs, Trios and Nuclear Families, Extended or Complete Pedigrees,
Phenotype
Trait TypeBinary or Qualitative, Quantitative,
DeterminantsSingle Genetic Marker, Multiple Genetic Markers, Sex-linked,
Evolutionary Features
Demographic
Population Size Changes
Gene Flow
Spatiality
Life Cycle
Mating System
Fecundity
Natural Selection
Determinant
Models
RecombinationUniform, Varying Recombination Rates,
Mutation ModelsTwo-allele Mutation Model,
Events Allowed
Other
InterfaceCommand-line,
Development
Tested PlatformsWindows, Mac OS X, Linux and Unix, Solaris,
LanguageC or C++,
LicenseOther (User sign-up at http://watson.hgen.pitt.edu/register/ is required),
GSR CertificationDocumentation, Application,

The following 5 publications are selected examples of applications that used FastSLINK.

2016

Peter B, Wijsman EM, Nato AQ Jr, Matsushita MM, Chapman KL, Stanaway IB, Wolff J, Oda K, Gabo VB, Raskind WH, Genetic Candidate Variants in Two Multigenerational Families with Childhood Apraxia of Speech., PLoS One, 01-01-2016 [Abstract]

Zou Q, The Generalized Relative Pairs IBD Distribution: Its Use in the Detection of Linkage., Front Public Health, 01-01-2016 [Abstract]

2015

Barral S, Vardarajan BN, Reyes-Dumeyer D, Faber KM, Bird TD, Tsuang D, Bennett DA, Rosenberg R, Boeve BF, Graff-Radford NR, Goate AM, et al., Genetic variants associated with susceptibility to psychosis in late-onset Alzheimer's disease families., Neurobiol Aging, 11-01-2015 [Abstract]

Barral S, Cheng R, Reitz C, Vardarajan B, Lee J, Kunkle B, Beecham G, Cantwell LS, Pericak-Vance MA, Farrer LA, Haines JL, et al., Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease., Alzheimers Dement, 12-01-2015 [Abstract]

2014

Garnai SJ, Huyghe JR, Reed DM, Scott KM, Liebmann JM, Boehnke M, Richards JE, Ritch R, Pawar H, Congenital cataracts: de novo gene conversion event in CRYBB2., Mol Vis, 01-01-2014 [Abstract]


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