Genetic Architecture Model Emulator for Testing and Evaluating Software: Simulates complex SNP models with pure, strict epistatic interactions with n-loci. Long Description (required)
Rapid, user friendly software package, able to generate whole populations of “worst-case-scenario” complex genetic models with random architectures, but a user specified set of constraints (i.e. number of loci, heritability, allele frequencies, prevalence). Intended for testing and evaluating algorithms or software for their ability to detect and model epistatic interactions in the absence of any main effects. The next version will add the ability to generate heterogeneous datasets (specifically datasets which concurrently contain both epistatic and heterogeneous effects. https://sourceforge.net/projects/gametes/?source=navbar
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Summary of Proposed Changes Current Citations/Applications
[Pubmed ID: 23025260 ],
Urbanowicz RJ, Kiralis J, Sinnott-Armstrong NA, Heberling T, Fisher JM, Moore JH ,
GAMETES: a fast, direct algorithm for generating pure, strict, epistatic models with random architectures. ,
BioData Min ,
10-01-2012 ,
https://www.ncbi.nlm.nih.gov/pubmed/?term=23025260, Primary Citation
[Pubmed ID: 36553670 ],
Sun Y, Gu Y, Ren Q, Li Y, Shang J, Liu JX, Guan B ,
MDSN: A Module Detection Method for Identifying High-Order Epistatic Interactions. ,
Genes (Basel) ,
12-18-2022 ,
https://www.ncbi.nlm.nih.gov/pubmed/?term=36553670, , Application
[Pubmed ID: 36818729 ],
Sha Z, Chen Y, Hu T ,
NSPA: characterizing the disease association of multiple genetic interactions at single-subject resolution. ,
Bioinform Adv ,
02-07-2023 ,
https://www.ncbi.nlm.nih.gov/pubmed/?term=36818729, , Application