GSR: Simulator - mbs

Basic Package Attributes
Title mbs
Short Description modifying Hudson's ms software to generate samples of DNA sequences with a biallelic site under selection
Long Description A software application to generate samples of DNA sequences when there is a biallelic site targeted by selection. mbs is developed by modifying Hudson's ms. The mbs software is so flexible that it can incorporate any arbitrary histories of population size changes and any mode of selection as long as selection is operating on a biallelic site.
Project Started 2008
Last Release 11 years, 10 months ago
Citations Teshima KM, Innan H, mbs: modifying Hudson's ms software to generate samples of DNA sequences with a biallelic site under selection., BMC Bioinformatics, 05-30-2009 [ Abstract, cited in PMC ]
GSR Certification


Last evaluated02-06-2020 (253 days ago)
Author verificationThe basic description provided was derived from a website or publications by the GSR team and has not yet been verified by the simulation author. To modify this entry or add more information, propose changes to this simulator.
Detailed Attributes
Attribute CategoryAttribute
Type of Simulated DataHaploid DNA Sequence,
VariationsBiallelic Marker,
Simulation MethodStandard Coalescent,
Data Type
File formatMS,
Data TypeGenotype or Sequence,
Sequencing Reads
File FormatMS,
Sample Type
Trait Type
Evolutionary Features
Population Size ChangesExponential Growth or Decline,
Gene FlowIsland Models,
Life Cycle
Mating SystemRandom Mating,
Natural Selection
ModelsDirectional Selection, Balancing Selection,
RecombinationVarying Recombination Rates,
Mutation Models
Events AllowedVarying Demographic Features,
Tested PlatformsMac OS X, Linux and Unix,
LanguageC or C++,
GSR CertificationDocumentation,

The following 8 publications are selected examples of applications that used mbs.


Kim KW, Jackson BC, Zhang H, Toews DPL, Taylor SA, Greig EI, Lovette IJ, Liu MM, Davison A, Griffith SC, et al., Genetics and evidence for balancing selection of a sex-linked colour polymorphism in a songbird., Nat Commun, 04-23-2019 [Abstract]


Alachiotis N, Pavlidis P, RAiSD detects positive selection based on multiple signatures of a selective sweep and SNP vectors., Commun Biol, 06-27-2018 [Abstract]

Mathieson S, Mathieson I, FADS1 and the Timing of Human Adaptation to Agriculture., Mol Biol Evol, 12-01-2018 [Abstract]


Ferrer-Admetlla A, Liang M, Korneliussen T, Nielsen R, On detecting incomplete soft or hard selective sweeps using haplotype structure., Mol Biol Evol, 05-01-2014 [Abstract]

Huerta-Sánchez E, Jin X, Asan, Bianba Z, Peter BM, Vinckenbosch N, Liang Y, Yi X, He M, Somel M, et al., Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA., Nature, 08-14-2014 [Abstract]


Wills DM, Whipple CJ, Takuno S, Kursel LE, Shannon LM, Ross-Ibarra J, Doebley JF, From many, one: genetic control of prolificacy during maize domestication., PLoS Genet, 06-01-2013 [Abstract]

Zhao L, Lascoux M, Overall AD, Waxman D, The characteristic trajectory of a fixing allele: a consequence of fictitious selection that arises from conditioning., Genetics, 11-01-2013 [Abstract]


Chan AH, Jenkins PA, Song YS, Genome-wide fine-scale recombination rate variation in Drosophila melanogaster., PLoS Genet, 01-01-2012 [Abstract]

Propose changes to this simulator