GSR: Simulator - PhenotypeSimulator
Attribute | Value |
---|---|
Title | PhenotypeSimulator |
Short Description | flexible simulation of phenotypes from different genetic and non-genetic (noise) components. |
Long Description | PhenotypeSimulator allows for the simulation of complex phenotypes under different models, including genetic variant effects and infinitesimal genetic effects (reflecting population structure) as well as correlated, non-genetic covariates and observational noise effects. Different phenotypic effects can be combined into a final phenotype while controlling for the proportion of variance explained by each of the components. For each component, the number of variables, their distribution and the design of their effect across traits can be customised. |
Version | 0..3.3 |
Project Started | 2018 |
Last Release | 4 years, 10 months ago |
Homepage | https://github.com/HannahVMeyer/PhenotypeSimulator |
Citations | Meyer HV, Birney E, PhenotypeSimulator: A comprehensive framework for simulating multi-trait, multi-locus genotype to phenotype relationships., Bioinformatics, 09-01-2018 [ Abstract, cited in PMC ] |
GSR Certification | ✔ Accessibility |
Last evaluated | 06-22-2021 (1005 days ago) |
Author verification | The basic description provided was derived from a website or publications by the GSR team and has not yet been verified by the simulation author. To modify this entry or add more information, propose changes to this simulator. |
Attribute Category | Attribute |
---|---|
Target | |
Type of Simulated Data | Phenotype, |
Variations | |
Simulation Method | |
Input | |
Data Type | |
File format | |
Output | |
Data Type | |
Sequencing Reads | |
File Format | |
Sample Type | |
Phenotype | |
Trait Type | |
Determinants | |
Evolutionary Features | |
Demographic | |
Population Size Changes | |
Gene Flow | |
Spatiality | |
Life Cycle | |
Mating System | |
Fecundity | |
Natural Selection | |
Determinant | |
Models | |
Recombination | |
Mutation Models | |
Events Allowed | |
Other | |
Interface | |
Development | |
Tested Platforms | Windows, Mac OS X, Linux and Unix, |
Language | R, |
License | Other, |
GSR Certification | Accessibility, Documentation, Application, Support, |
Number of Primary Citations: 1
Number of Non-Primary Citations: 2
The following 2 publications are selected examples of applications that used PhenotypeSimulator.
2022
Zeng B, Bendl J, Kosoy R, Fullard JF, Hoffman GE, Roussos P, Multi-ancestry eQTL meta-analysis of human brain identifies candidate causal variants for brain-related traits., Nat Genet, 02-01-2022 [Abstract]
Swart Y, van Eeden G, Uren C, van der Spuy G, Tromp G, Möller M, GWAS in the southern African context., PLoS One, 09-28-2022 [Abstract]