GSR: Editing - SIMCOAL2 Simulator

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SIMCOAL2
A coalescent program for the simulation of complex recombination patterns over large genomic regions under various demographic models
We present here SIMCOAL2, an extended version of the SIMCOAL program (Excoffier et al. 2000), to simulate the neutral genetic diversity at partially linked loci under different histories and a wide range of migration and demographic models. SIMCOAL2 includes a number of new features compared to the previous version: The possibility of arbitrary recombination rates between adjacent loci Multiple coalescent events per generation, allowing the correct simulation of very large samples and very large recombining genomic regions The simulation of SNP data with arbitrary minimum frequency, for instance to simulate ascertainment bias The output of diploid genotypic data generated under the assumption of Hardy-Weinberg equilibrium The simulation of a mixture of different data types (DNA sequence, RFLP, STR, or SNP) along a single chromosome.
2.1.2
01-01-2000
01-01-2005
http://cmpg.unibe.ch/software/simcoal2/
None

Attribute Tree Control

Step 1: Use the attribute tree to add new attributes or remove pre-selected attributes to describe the simulator.

Every sub-attribute is selected
Not all sub-attributes are selected
  • Target
    • Type of Simulated Data
      • Genotype at Genetic Markers
      • Diploid DNA Sequence
      • Haploid DNA Sequence
      • RNA
      • Sex Chromosomes
      • Mitochondrial DNA
      • Protein Sequence
      • Sequencing Reads
      • Phenotype
    • Variations
      • Biallelic Marker
      • Multiallelic Marker
      • Single Nucleotide Variation
      • Amino acid variation
      • Microsatellite
      • Insertion and Deletion
      • CNV
      • Inversion and Rearrangement
      • Alternative Splicing
      • Missing Genotypes
      • Genotype or Sequencing Error
      • Other
  • Simulation Method
    • Standard Coalescent
    • Exact Coalescent
    • Machine Learning
    • Forward-time
    • Resample Existing Data
    • Phylogenetic
    • Gene dropping
    • Other
  • Input
    • Data Type
      • Allele Frequencies
      • Empirical
      • Ancestral Sequence
      • Saved simulation
      • Reference genome
      • Other
    • File format
      • Arlequin
      • CREATE
      • Fstat
      • GDA
      • Genepop
      • MIGRATE
      • MS
      • SAM or BAM
      • NEXUS
      • Phylip
      • STRUCTURE
      • XML
      • Tree Sequence
      • Program Specific
      • Other
  • Output
    • Data Type
      • Genotype or Sequence
      • Phenotypic Trait
      • Individual Relationship
      • Demographic
      • Mutation
      • Methylation
      • Gene Expression
      • Protein Expression
      • Linkage Disequilibrium
      • Diversity Measures
      • Fitness
      • Sequencing Reads
        • Illumina
        • Roche 454
        • SOLiD
        • IonTorrent
        • PacBio
        • Nanopore
        • Other
      • Other
    • File Format
      • Arlequin
      • Fasta or Fastq
      • Fstat
      • Genepop
      • Linkage
      • MIGRATE
      • MS
      • PED
      • Phylip
      • NEXUS
      • STRUCTURE
      • VCF
      • SAM or BAM
      • Tree Sequence
      • Program Specific
      • Other
    • Sample Type
      • Random or Independent
      • Sibpairs, Trios and Nuclear Families
      • Extended or Complete Pedigrees
      • Case-control
      • Longitudinal
      • Other
  • Phenotype
    • Trait Type
      • Binary or Qualitative
      • Quantitative
      • Multiple
    • Determinants
      • Single Genetic Marker
      • Multiple Genetic Markers
      • Sex-linked
      • Gene-Gene Interaction
      • Environmental Factors
      • Gene-Environment Interaction
  • Evolutionary Features
    • Demographic
      • Population Size Changes
        • Constant Size
        • Exponential Growth or Decline
        • Logistic Growth
        • Bottleneck
        • Carrying Capacity
        • User Defined
      • Gene Flow
        • Stepping Stone Models
        • Island Models
        • Continent-Island Models
        • Sex or Age-Specific Migration Rates
        • Influenced by Environmental Factors
        • Admixed Population
        • User-defined Matrix
        • Other
      • Spatiality
        • Discrete Models
        • Continuous Models
        • Landscape Factors
    • Life Cycle
      • Discrete Generation Model
      • Age structured
      • Overlapping Generation
      • User-Defined transition matrices
    • Mating System
      • Random Mating
      • Monogamous
      • Polygamous
      • Haplodiploid
      • Selfing
      • Age- or Stage-Specific
      • Assortative or Disassortative
      • Other
    • Fecundity
      • Constant Number
      • Randomly Distributed
      • Individually Determined
      • Influenced by Environment
      • Other
    • Natural Selection
      • Determinant
        • Single-locus
        • Multi-locus
        • Codon-based
        • Fitness of Offspring
        • Phenotypic Trait
        • Environmental Factors
      • Models
        • Directional Selection
        • Balancing Selection
        • Multi-locus models
        • Epistasis
        • Random Fitness Effects
        • Disruptive
        • Phenotype Threshold
        • Frequency-Dependent
        • Other
    • Recombination
      • Uniform
      • Varying Recombination Rates
      • Gene Conversion Allowed
    • Mutation Models
      • Two-allele Mutation Model
      • Markov DNA Evolution Models
      • k-Allele Model
      • Infinite-allele Model
      • Infinite-sites Model
      • Stepwise Mutation Model
      • Codon and Amino Acid Models
      • Indels and Others
      • Heterogeneity among Sites
      • Others
    • Events Allowed
      • Population Merge and Split
      • Varying Demographic Features
      • Population Events
      • Varying Genetic Features
      • Change of Mating Systems
      • Other
    • Other
      • Phenogenetic
      • Polygenic background
  • Interface
    • Command-line
    • Graphical User Interface
    • Integrated Development Environment
    • Script-based
    • Web-based
  • Development
    • Tested Platforms
      • Windows
      • Mac OS X
      • Linux and Unix
      • Solaris
      • Others
    • Language
      • C or C++
      • Java
      • R
      • Python
      • Perl
      • Visual Basic
      • Other
    • License
      • GNU Public License
      • BSD
      • Creative Commons
      • MIT
      • Other
  • GSR Certification
    • Accessibility
    • Documentation
    • Application
    • Support

Summary of Proposed Changes

Step 2: Review list of proposed attribute addition(s) and subtraction(s).

To Add

    To Remove

      Can't Find the Attribute You Are Looking For?

      If you would like to propose an attribute that you cannot find in the tree above, or if you would like to add a clarification to one or more attributes for this simulator (e.g. a specific file format for attribute /Output/File Format/Other), please list them in the Additional Comment box of the Submit tab.

      You may add citations by pmid, add citations by direct entry, remove citations (using the recycling bin icon), and edit citations (using the rarely seen edit icon) that were originally entered by direct entry.

      Summary of Proposed Changes

      To Add

      To Remove

      Current Citations/Applications

      [Pubmed ID: 11218093], Excoffier L, Novembre J, Schneider S, SIMCOAL: a general coalescent program for the simulation of molecular data in interconnected populations with arbitrary demography., J Hered, 11-01-2000, https://www.ncbi.nlm.nih.gov/pubmed/?term=11218093,Primary Citation
      [Pubmed ID: 15117750], Laval G, Excoffier L, SIMCOAL 2.0: a program to simulate genomic diversity over large recombining regions in a subdivided population with a complex history., Bioinformatics, 10-12-2004, https://www.ncbi.nlm.nih.gov/pubmed/?term=15117750,Primary Citation
      [Pubmed ID: 28635966], Rovito SM, Schoville SD, Testing models of refugial isolation, colonization and population connectivity in two species of montane salamanders., Heredity (Edinb), 10-01-2017, https://www.ncbi.nlm.nih.gov/pubmed/?term=28635966,, Application
      [Pubmed ID: 29343863], Sharma R, Goossens B, Heller R, Rasteiro R, Othman N, Bruford MW, Chikhi L, Genetic analyses favour an ancient and natural origin of elephants on Borneo., Sci Rep, 01-17-2018, https://www.ncbi.nlm.nih.gov/pubmed/?term=29343863,, Application
      [Pubmed ID: 30575786], Pérez-Pardal L, Sánchez-Gracia A, Álvarez I, Traoré A, Ferraz JBS, Fernández I, Costa V, Chen S, Tapio M, Cantet RJC, et al., Legacies of domestication, trade and herder mobility shape extant male zebu cattle diversity in South Asia and Africa., Sci Rep, 12-21-2018, https://www.ncbi.nlm.nih.gov/pubmed/?term=30575786,, Application
      [Pubmed ID: 31871624], Pirog A, Ravigné V, Fontaine MC, Rieux A, Gilabert A, Cliff G, Clua E, Daly R, Heithaus MR, Kiszka JJ, et al., Population structure, connectivity, and demographic history of an apex marine predator, the bull shark <i>Carcharhinus leucas</i>., Ecol Evol, 09-30-2019, https://www.ncbi.nlm.nih.gov/pubmed/?term=31871624,, Application
      [Pubmed ID: 32874654], Victoriano PF, Muñoz-Ramírez CP, Canales-Aguirre CB, Jara A, Vera-Escalona I, Burgos-Careaga T, Muñoz-Mendoza C, Habit EM, Contrasting evolutionary responses in two co-distributed species of <i>Galaxias</i> (Pisces, Galaxiidae) in a river from the glaciated range in Southern Chile., R Soc Open Sci, 07-08-2020, https://www.ncbi.nlm.nih.gov/pubmed/?term=32874654,, Application
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