GSR: Simulator - tHapMix

AttributeValue
Title tHapMix
Short Description Haplotype-based simulator for tumour whole-genome sequencing data.
Long Description tHapMix generates somatic copy-number and SNV variants on cancer evolutionary trees to produce polyclonal tumour samples with configurable ploidy, purity, heterogeneity, clone number, clone tree structure, major clone fraction, and private variant fraction.
Keywords tumour simulation; cancer genomics; haplotype mixture; whole-genome sequencing; copy number variation; SNV; Python
Version 2026-04-20
Homepagehttps://github.com/Illumina/tHapMix
Citations
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Author verificationThe basic description provided was derived from a website or publications by the GSR team and has not yet been verified by the simulation author. To modify this entry or add more information, propose changes to this simulator.
Attribute CategoryAttribute
Target
Type of Simulated DataGenotype at Genetic Markers, Haploid DNA Sequence, Sequencing Reads,
VariationsSingle Nucleotide Variation,
Simulation Method
Input
Data TypeReference genome,
File format
Output
Data TypeGenotype or Sequence,
Sequencing Reads
File FormatFasta or Fastq,
Sample Type
Phenotype
Trait Type
Determinants
Evolutionary Features
Demographic
Population Size Changes
Gene Flow
Spatiality
Life Cycle
Mating System
Fecundity
Natural Selection
Determinant
Models
Recombination
Mutation Models
Events Allowed
Other
InterfaceCommand-line, Script-based,
Development
Tested PlatformsLinux and Unix,
LanguagePython,
License
GSR Certification

Number of Primary Citations: 0

Number of Non-Primary Citations: 0

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