GSR: Simulator - SIBSIM

Basic Package Attributes
AttributeValue
Title SIBSIM
Short Description Quantitative phenotype simulation in extended pedigrees
Long Description SIBSIM is a modern and powerful computer program to simulate genotype and quantitative trait data in extended pedigrees. In the current release (2.1.2), we put emphasis on the simulation of a quantitative trait in pedigrees of arbitrary size without monozygotic twins. Well known software as, e.g., the SIMULATE package are not as scalable as SIBSIM. As an advantage over both G.A.S.P. and SIMLA no predefined boundaries restrict SIBSIM in its potential, neither in genome nor in family size. Instead, SIBSIM is as highly scalable as possible to meet any needs. SIBSIM may not only be used in simulation studies, but also in the validation, verification and testing process of other applications which deal with the implementation of statistical analysis of genomic data. We successfully used SIBSIM in the latter respect and detected a bug in a widely used genetic epidemiological software package.
Version 2.1.2
Project Started 2004
Last Release 13 years, 9 months ago
Homepagehttp://sourceforge.net/projects/sibsim/
Citations Franke D, Kleensang A, Ziegler A, SIBSIM - quantitative phenotype simulation in extended pedigrees , GMS Med Inform Biom Epidemiol , 02-21-2006 [ Abstract ]
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Last evaluated02-25-2020 (234 days ago)
Author verificationThe basic description provided was derived from a website or publications by the GSR team and has not yet been verified by the simulation author. To modify this entry or add more information, propose changes to this simulator.
Detailed Attributes
Attribute CategoryAttribute
Target
Type of Simulated DataGenotype at Genetic Markers,
VariationsBiallelic Marker, Missing Genotypes,
Simulation MethodOther,
Input
Data TypeAllele Frequencies,
File formatXML,
Output
Data TypeGenotype or Sequence,
Sequencing Reads
File FormatLinkage,
Sample TypeSibpairs, Trios and Nuclear Families, Extended or Complete Pedigrees,
Phenotype
Trait TypeQuantitative,
DeterminantsSingle Genetic Marker (Single di-allelic quantitative trait marker),
Evolutionary Features
Demographic
Population Size ChangesConstant Size,
Gene Flow
Spatiality
Life Cycle
Mating System
Fecundity
Natural Selection
Determinant
Models
Recombination
Mutation Models
Events Allowed
Other
InterfaceCommand-line,
Development
Tested PlatformsLinux and Unix,
LanguageC or C++,
LicenseGNU Public License,
GSR CertificationAccessibility,

The following 1 publications are selected examples of applications that used SIBSIM.

2011

König IR, Schumacher J, Hoffmann P, Kleensang A, Ludwig KU, Grimm T, Neuhoff N, Preis M, Roeske D, Warnke A, et al., Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21., Am J Med Genet B Neuropsychiatr Genet, 01-01-2011 [Abstract]


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