Quantitative phenotype simulation in extended pedigrees Long Description (required) SIBSIM is a modern and powerful computer program to simulate genotype and quantitative trait data in extended pedigrees. In the current release (2.1.2), we put emphasis on the simulation of a quantitative trait in pedigrees of arbitrary size without monozygotic twins. Well known software as, e.g., the SIMULATE package are not as scalable as SIBSIM. As an advantage over both G.A.S.P. and SIMLA no predefined boundaries restrict SIBSIM in its potential, neither in genome nor in family size.
Instead, SIBSIM is as highly scalable as possible to meet any needs. SIBSIM may not only be used in simulation studies, but also in the validation, verification and testing process of other applications which deal with the implementation of statistical analysis of genomic data. We successfully used SIBSIM in the latter respect and detected a bug in a widely used genetic epidemiological software package. http://sourceforge.net/projects/sibsim/ None Step 1: Use the attribute tree to add new attributes or remove pre-selected attributes to describe the simulator. Every sub-attribute is selected Not all sub-attributes are selected Fill Clear Expand Collapse Reset Summary of Proposed Changes Step 2: Review list of proposed attribute addition(s) and subtraction(s). Can't Find the Attribute You Are Looking For?
If you would like to propose an attribute that you cannot find in the tree above, or if you would like to add a clarification to one or more attributes for this simulator (e.g. a specific file format for attribute /Output/File Format/Other), please list them in the
Additional Comment box of the Submit tab. Summary of Proposed Changes Current Citations/Applications ,
SIBSIM - quantitative phenotype simulation in extended pedigrees GMS Med Inform Biom Epidemiol ,
http://www.egms.de/static/en/journals/mibe/2006-2/mibe000021.shtml, Primary Citation
Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21. Am J Med Genet B Neuropsychiatr Genet,
https://www.ncbi.nlm.nih.gov/pubmed/?term=21184582, , Application